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Exclamation points indicate emotion, an outcry, or a forceful comment. Try to avoid their use except in direct quotations and in rare and special circumstances. They are not appropriate in scientific manuscripts and are more common in less formal articles, such as book reviews, editorials, and informal essays, where added emphasis may be appropriate. If they are used, limit their use to one.Beware! Although it may be referred to as the gold standard, nothing is perfect! I had almost given up hope of his recovery. He was terribly sick! When it completes the emphasized material, the exclamation point goes inside Less

Periods are the most common end-of-sentence punctuation marks. Use a period at the end of a declarative or imperative sentence and at the end of each table footnote and each figure legend.Advances in medical technology have saved many lives. Always listen carefully. Also use a period after a rhetorical question (one not requiring an answer).Where, indeed, is the Osler of today. The period precedes ending quotation marks and reference citations.The child is rated in 7 areas, such as “accepts responsibility” and “interacts appropriately with peers.” We followed the methods of Wilkes et al. The period follows a closing apostrophe: Their Less

…after journeying through the world of punctua- tion, and seeing what it can do, I am all the more convinced that we should fight like tigers to preserve our punctuation and we should start now.     Lynne Truss Periods, question marks, and exclamation points are the 3 end-of-sentence punctuation marks. | Periods are the most common end-of-sentence punctuation marks. Use a period at the end of a declarative or imperative sentence and at the end of each table footnote and each figure legend.Advances in medical technology have saved many lives. Always listen carefully. Also use a period after a rhetorical question (one Less

The primary use of the question mark is to end interrogative sentences.When did he go into private practice? If this article were a work of the 1930s, not the 1990s, would we view it differently? And should we? Use the question mark to show doubt about specific data.Hippocrates (460?-375 bce) is often referred to as the Father of Medicine. Place the question mark inside the end quotation mark (see , Quotation Marks, Placement), the closing parenthesis, or the end bracket when the question mark is part of the quoted or parenthetical material.The patient asked her physician of 25 years, “Why Less