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  • 20.2 Randomized Controlled Trials. x
  • 20 Study Design and Statistics x
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Crossover Trials  

Margaret A. Winker and Stephen J. Lurie

in AMA Manual of Style: A Guide for Authors and Editors (10th edition)

Print Publication Year: 
2007
Published Online: 
2009
DOI: 
10.1093/jama/9780195176339.022.600
Item type: 
section
In a crossover trial, participants receive more than 1 of the treatments under investigation, usually in a randomly determined sequence, and with a prespecified amount of time (a ) between sequential ... More

Equivalence and Noninferiority Trials  

Margaret A. Winker and Stephen J. Lurie

in AMA Manual of Style: A Guide for Authors and Editors (10th edition)

Print Publication Year: 
2007
Published Online: 
2009
DOI: 
10.1093/jama/9780195176339.022.601
Item type: 
section
It is sometimes desirable to compare a less expensive treatment or intervention against a treatment or intervention that is already known to be effective. In these cases, it would be unethical to expose ... More

Parallel-Design Double-blind Trials  

AMA Manual of Style Committee

in AMA Manual of Style: A Guide for Authors and Editors (10th edition)

Print Publication Year: 
2007
Published Online: 
2009
DOI: 
10.1093/jama/9780195176339.022.599
Item type: 
section
In this study design, participants are assigned to only 1 treatment group of the study. These trials are generally designed to assess whether 1 or more treatments are superior to the others. Participants ... More

Randomized Controlled Trials  

Margaret A. Winker and Stephen J. Lurie

in AMA Manual of Style: A Guide for Authors and Editors (10th edition)

Print Publication Year: 
2007
Published Online: 
2009
DOI: 
10.1093/jama/9780195176339.021.278
Item type: 
section
The randomized controlled trial (RCT) generally leads to the strongest inferences about the effect of medical treatments. Randomized controlled trials assess efficacy of the treatment intervention in ... More

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