Cost-effectiveness Analysis, Cost-Benefit Analysis - AMA Manual of Style

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Cost-effectiveness Analysis, Cost-Benefit Analysis 

Study Design and Statistics

Margaret A. Winker

and Stephen J. Lurie

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PRINTED FROM AMA MANUAL OF STYLE ONLINE ( © American Medical Association, 2009. All Rights Reserved. Under the terms of the license agreement, an individual user may print out a PDF of a single chapter of a title in AMA Manual of Style Online for personal use (for details see Privacy Policy). date: 30 November 2015

Although a treatment or screening technique may be shown to be effective in an RCT, recommending it in general practice would not necessarily be rational. Such interventions may be prohibitively expensive, or they may benefit only a small number of people at the expense of a large number of people, or they may lead to significant “downstream” costs that would eventually negate any immediate savings or benefit. Thus, it is possible that interventions that appear less effective may actually lead to the greatest societal benefits over the long term. Cost-effectiveness and cost-benefit analyses comprise a set of mathematical techniques to

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