Platelet-Specific Antigens - AMA Manual of Style

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Platelet-Specific Antigens 

Platelet-Specific Antigens

Chapter:
Nomenclature
Author(s):

Harriet S. Meyer

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Platelet-Specific Antigens

The current system of human platelet antigen (HPA) nomenclature, adopted in 1990, is overseen by the Platelet Nomenclature Committee of the ISBT and the International Society on Thrombosis and Haemostasis.19-21 As with blood groups, there are platelet antigen systems and specific antigens within those systems. The HPA nomenclature pertains to “all protein alloantigens expressed on the platelet membrane, except those coded by genes of the major histocompatibility complex (MHC).”21(p241) (See 15.8.5, Immunology, HLA/Major Histocompatibility Complex.) Currently, there are 6 HPA systems: HPA-1, HPA-2, HPA-3, HPA-4, HPA-5, and HPA-15.21

Complete tables of HPA terms are available at the IPD-HPA Database, http://www.ebi.ac.uk/ipd/hpa/.21 Sample terms include the following:

Antigen system:

HPA-1

Associated glycoprotein:

GpIIIa

CD designation of glycoprotein:

CD61

Former names:

Zw, P1A

Antigens:

HPA-1a

HPA-1b

Former names:

Zwa, P1A1

Zwb, P1A2

Gene:

ITGB3

Alleles:

ITGB3*001

ITGB3*002

Epitopes:

HPA-1a

HPA-1b

Locuslink ID:

3690

Ref_Seq:

NM_000212

Swiss-Prot:

ITB3_Human

Nucleotide change:

176T>C

For CD (clusters of differentiation) nomenclature, see 15.8.7, Immunology, Lymphocytes. For gene and allele nomenclature, see 15.6.2, Genetics, Human Gene Nomenclature. For database identifiers and nucleotide nomenclature, see 15.6.1 Genetics, Nucleic Acids and Amino Acids.

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