Cancer stages are expressed with the use of capital roman numerals:
The term “stage 0” usually indicates carcinoma in situ.
Histologic grades are expressed with arabic numerals, eg, grade 2.
Letter and numerical suffixes, usually set on the line, may be added to subdivide individual cancer stages, as in the following examples:
(E indicates extralymphatic spread; S, splenic involvement [as seen in Hodgkin disease]; “is,” in situ.)