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Contents

Bethesda System 

Chapter:
Nomenclature
Author(s):

Harriet S. Meyer

Bethesda System

The Bethesda System for Reporting Cervical Cytology, dating to 1988, is a standardized, systematic means of reporting Papanicolaou test results.14 Resources are the published handbook (the “blue book”)14 and the website (http://www.cytopathology.org/NIH).15

Expand the following abbreviations at first mention. Punctuate as shown:

Expansion

Abbreviation

adenocarcinoma in situ of endocervix

AIS

American Society for Colposcopy and Cervical Pathology

ASCCP

American Society of Cytopathology

ASC

ASCUS/LSIL Triage Study

ALTS

atypical glandular cells

AGCs

atypical squamous cells

ASCs

atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion

ASC-H

atypical squamous cells of undetermined significance

ASC-US

Bethesda Interobserver Reproducibility Project

BIRP

carcinoma in situ

CIS

cervical intraepithelial neoplasia

CIN

conventional preparation

CP

endocervical/transformation zone

EC/TZ

high-grade squamous intraepithelial lesion

HSIL

human papillomavirus

HPV

intrauterine device or intrauterine contraceptive device

IUD

liquid-based preparation

LBP

loop electrosurgical excision procedure

LEEP

last menstrual period

LMP

lower uterine segment

LUS

low-grade squamous intraepithelial lesion

LSIL

malignant mixed mesodermal tumor

MMMT

National Cancer Institute, Bethesda, Maryland

NCI

negative for intraepithelial lesion or malignancy

NILM

not otherwise specified

NOS

nuclear to cytoplasmic ratio

N:C

small cell undifferentiated carcinoma

SCUC

squamous intraepithelial lesion

SIL

the Bethesda System

TBS

transitional cell carcinoma

TCC

transformation zone

T zone

vaginal intraepithelial neoplasia

VAIN

In the following examples, unexpanded abbreviations are assumed to have been previously defined in the text:

Low-grade squamous intraepithelial lesions (LSILs) have been described as a benign cytologic consequence of active human papillomavirus (HPV) replication. Several studies have reported that certain behavioral and biological risks exist for LSIL, suggesting that HPV alone is not sufficient for the development of LSIL.

AIS (CP)

ASC-H (CP)

exfoliated endometrial cells (liquid-based preparation [LBP])

atrophy (LBP)

glandular cells post hysterectomy (CP)

Grades are expressed as follows:

CIN 1, CIN 2, CIN 3

VAIN 1, VAIN 2, VAIN 3

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