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Contents

Molecular Cancer Terminology 

Chapter:
Nomenclature
Author(s):

Harriet S. Meyer

Molecular Cancer Terminology

See also 15.10, Molecular Medicine. The style for the cell cycle is as follows:

Phase

Expansion or Derivation

G1

growth 1 or gap 1

S

synthesis (of DNA)

G2

growth 2 or gap 2

M

mitosis

G0

quiescent state

R point

restriction point

Miscellaneous molecular terms are styled as shown in the following tabulation. (See also 15.6.3, Genetics, Oncogenes and Tumor Suppressor Genes.)

Protein

Derivation

Variant Examples

Associated Genes

actinin

α-actinin

ACTN1, ACTN2, ACTN3

Bcl

B-cell lymphoma

bcl-2

BCL2

CAK

cyclin-activating enzyme (= cyclinH/CDK7)

bcl-X

BCLX

catenin

β1-catenin

CTNNB1

cdc2

cell division cycle

CDC2

CDK

cyclin-dependent kinase

cdk2

CDK2

CDKI

CDK inhibitor

cyclin/CDK complex

cyclin B/CDK1, cyclinD/CDK4/CDK6

G protein

GTP-binding regulatory protein

INK4

inhibitors of CDK4

p16Ink4 (p16)

CDKN2A

p21

CDKN1A

p53

TP53

Rb protein

retinoblastoma protein

RB1

TGF

tumor (or transforming) growth factor

TGF-β

tumor necrosis factor (TNF)

TNF

Note: Gene terms follow standard gene nomenclature style (see 15.6.2, Genetics, Human Gene Nomenclature).

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