Endothelial Factors
15.7.2 Endothelial Factors
Structures and products of endothelial cells—the cells lining blood vessels—maintain blood fluidity by preventing excessive clotting and prevent bleeding by promoting clotting. The following endothelium-associated terms are presented as a guide to style.
Class |
Term |
Abbreviation |
|---|---|---|
cellular (or cell) adhesion molecules |
CAMs |
|
intercellular adhesion molecule 1 |
ICAM-1 |
|
intercellular adhesion molecule 2 |
ICAM-2 |
|
platelet-endothelial CAM |
PECAM |
|
vascular CAM 1 |
VCAM-1 |
|
cytokines (see also 15.8.4, Immunology, Cytokines) |
||
gro (growth-stimulating factor) |
||
RANTES (regulated on activation, normal T-expressed, and presumably secreted3) |
||
integrins |
||
α1β1 integrin |
||
α2β3 integrin |
||
α3β1 integrin |
||
α6β1 integrin |
||
αvβ1 integrin |
||
αvβ3 integrin |
||
miscellaneous |
||
nitric oxide |
NO |
|
endothelial (or epithelial) NO synthase |
eNOS (also NOS3) |
|
endothelial-cell associated ADPase (CD39; see also 15.8.7, Immunology, Lymphocytes) |
||
prostacyclin, prostaglandin I2 |
PGI2 |
|
E-selectin |
||
L-selectin |
||
P-selectin |
||
tissue plasminogen activator (see 15.7.4, Inhibition of Coagulation and Fibrinolysis) |
tPA |
|
urokinase or urinary plasminogen activator (see 15.7.4, Inhibition of Coagulation and Fibrinolysis) |
uPA |
Three glycoprotein complexes are synonymous with 3 integrins and take part in hemostasis:
GpIa-IIa |
α2β1 |
GpIc-IIa |
α6β1 |
GpIIb-IIIa |
αIIBβ3 |