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Contents

CD Cell Markers 

Chapter:
Nomenclature
Author(s):

Harriet S. Meyer

CD Cell Markers

Clusters of differentiation (CDs) are a system for identifying cellular surface markers, a number of which define lymphocyte subsets (see 15.8.7, Lymphocytes).7-12 The system and its nomenclature were formalized in a 1982 international workshop. Originally CD terms specified the monoclonal antibodies (mAbs) that clustered statistically in their reactivities to target cells. More recently, the CD terms apply to the cellular molecules themselves. The CDs, which now number more than 200 (and may eventually number in the thousands12), are defined at the Human Cell Differentiation Molecules workshops (formerly Human Leukocyte Differentiation Antigen Workshops). Workshops involve “multiple laboratories examining coded panels of antibodies [with] multilaboratory blind analysis and statistical evaluation of the results.”11(p226) Although reactivity and cellular expression originally were key in identifying CDs, gene-based molecular relatedness has become an important determinant.11,12

See the Human Cell Differentiation Molecules website (http://www.hlda8.org) for updates on the most recent workshop and conference, including confirmed, validated antibodies and newly assigned CDs.13

Some CDs are known most commonly by their CD designation. Other molecules have been assigned CD numbers retroactively; although they will be referred to by their common names, it is useful for authors to include the CD designations.11 Terms related to CDs do not need to be expanded. See the following examples.

CD Terms

Other Name(s)13

CD1a

CD3d

CD3 complex

CD4

(see also 15.8.7, Lymphocytes)

CD6

CD8α

(see also 15.8.7, Lymphocytes)

CD10

CALLA (common acute lymphoblastic leukemia antigen), neprilysin; enkephalinase; membrane metalloendopeptidase

CD16a

FcγRIIIa (an Fc receptor; see also 15.8.6, Immunoglobulins)

CD35

C3b/C4b receptor; complement receptor type 1 (CR1; see also 15.8.3, Complement)

CD41

glycoprotein IIb (see also 15.1.2, Platelet-Specific Antigens)

CD44R

CD44 variant; CD44v1-10

CD46

membrane cofactor protein (MCP; see also the “Complement Regulators” section in 15.8.3, Complement)

CD50

intracellular adhesion molecule 3 (ICAM-3)

CD55

delay accelerating factor (DAF; see also 15.8.3, Complement)

CD62P

P-selectin; granule membrane protein-140 (GMP-140)

CD79a

Igα (see also 15.8.6, Immunoglobulins); MB-1

CD97

BL-KDD/F12

CD107a

lysosomal-associated membrane protein 1 (LAMP-1)

CD120a

tumor necrosis factor receptor (TNFR) type 1; TNFR p55

CD139

CD195

CCR5 (see 15.8.1, Chemokines)

CD213a2

IL-13Rα2 (see also the “Interleukins” section in 15.8.4, Cytokines)

CD220

insulin receptor

CD235a

glycophorin a

CD240CE

Rh blood group, CcEe antigens (see also 15.1.1, Blood Groups)

A lowercase w (for “workshop”) signifies a provisional cluster (which is likely to become final, and have the w dropped, in an upcoming workshop11):

CDw186

The new designation of CDw128A is CD181.

Complexes of more than 1 CD molecule are indicated with a forward slash or virgule:

CD11a/CD18 (leukocyte functional antigen 1 [LFA-1])

CD11b/CD18 (CR3 or C3bi receptor; see 15.8.3, Complement)

CD49c/CD29

The CD nomenclature displaced previous terms, eg, CD8 for T8 or OKT8, CD4 for T4 or OKT4, CD5 for Leu-1, Lyt-1, CD5 for T1.

For therapeutic monoclonal antibody nomenclature, see 15.4, Drugs.

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