Molecular Neuroscience
15.11.5 Molecular Neuroscience
The following terms are provided for reference (a major source is Nestler et al20) (see also 15.10, Molecular Medicine). Terms with asterisks need not be expanded; others should be expanded at first mention.
Term |
Expansion or Explanation |
|---|---|
α-adrenergic receptor, α receptor* (subtypes: α1A, α1B, α1D, α2A, α2B, α2C) |
|
α-synuclein |
|
A1, A2* |
neuropeptide adenosine receptors (also known as purine receptors P1, P2; see also 15.6.1, Genetics, Nucleic Acids and Amino Acids) |
ACh |
acetylcholine |
AChE |
acetylcholinesterase |
AMPA |
α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid class of glutamate receptor |
β-adrenergic receptor, β receptor* (subtypes: β1, β2, β3) |
|
BDNF |
brain-derived neurotrophic factor |
CCR3, CCR5, CXCR4 |
chemokine receptors (see 15.8.1, Immunology, Chemokines) |
Ch1 through Ch8 |
cholinergic nuclei |
CNTF |
ciliary neurotrophic factor |
COMT |
catechol-O-methyltransferase |
cytokines |
(see 15.8.4, Immunology, Cytokines) |
δ-receptor |
opioid δ receptor |
D1 through D5 |
dopamine receptors |
DAT |
dopamine transporters |
EAAT1 EAAT2 EAAT3 EAAT4 EAAT5 |
excitatory amino acid reuptake transporters |
EGF |
epidermal growth factor |
GABA |
γ-aminobutyric acid |
GABAA, GABAB |
GABA receptor classes |
GABAergic |
GABA-mediated |
GABA-T |
GABA transaminase |
GAT-1, GAT-2, GAT-3, GAT-4 |
GABA family transporters |
GDNF |
glial cell line-derived neurotrophic factor |
GFR |
GDNF-neurturin receptor |
GIRKs |
G protein-coupled Kir3 channels |
H1, H2, H3 |
histamine receptors |
5-HT |
5-hydroxytryptamine, serotonin (preferred expansion) |
5-HT1A, 5-HT1B, 5-HT2A, 5-HT5B, 5-HT7 |
5-HT receptors |
5-HTT |
serotonin transporter |
5HTTLPR |
a polymorphism of the serotonin transporter gene (LPR: length polymorphism region) (see also 15.6.2, Genetics, Human Gene Nomenclature) |
interleukins |
(see 15.8.4, Immunology, Cytokines) |
IP3 |
inositol triphosphate |
κ-receptor |
opioid κ receptor |
K(ATP) channel |
potassium channel |
K(Ca) |
Ca2+-gated K+ channel |
Kir1, Kir2, Kir3, Kir4, Kir5* |
inwardly rectifying K+ channels |
L channels, L-type channels* |
large-current or long-open-time Ca2+ channels |
μ-receptor |
opioid μ receptor |
M1 through M5* |
muscarinic receptors |
MAO |
monoamine oxidase |
MAOA, MAOB |
major forms of MAO |
N channels* |
neuronal Ca2+ channels |
nAChRs |
nicotinic acetylcholine receptors |
NET |
norepinephrine GABA family transporter |
neuromedin B* |
|
neuromedin K* |
|
neuropeptide Y* |
|
NGF |
nerve growth factor |
NK1 NK2 NK3 |
neuromedin K tachykinin receptors |
NMDA |
N-methyl-d-aspartate class of glutamate receptor |
nNOS (also NOS1) |
neuronal nitric oxide synthetase |
NSF |
N-ethylmaleamide sensitive factor |
NT-3, NT-4 |
neurotrophin 3 and neurotrophin 4 |
NTS1, NTS2 |
neurotensin receptors |
P channels* |
Purkinje Ca2+ channels |
P1, P2* |
neuropeptide purine receptors (also known as adenosine receptors A1, A2; see also 15.6.1, Genetics, Nucleic Acids and Amino Acids) |
R-PTK |
receptor-associated protein tyrosine kinase |
σ-receptor |
opioid σ receptor |
SERT |
serotonin GABA family transporter |
SNAP-25 |
synaptosomal aassociated protein of 25 kDa |
SNAPs |
soluble NSF attachment proteins (note different expansion of SNAP than for SNAP-25) |
SNARE proteins |
SNAP receptors |
SNAREpins |
hairpin forms of SNARE proteins |
substance P* |
|
T channels* |
transient Ca2+ channels |
t-SNARES |
t: target membranes |
VAChT |
vesicular transporters of ACh |
VAMP |
vesicle-associated membrane protein, synaptobrevin |
VGAT |
vesicular transporter for GABA |
VGlutT1 |
vesicular transporter for glutamate |
VMAT1 |
vesicular transporter for monoamines |
v-SNARE |
v: vesicle |
Y1, Y2, Y4, Y5, Y6 |
neuropeptide Y receptors |
Gene symbols for many of the above terms are found in the list of genes in 15.6.2, Genetics, Human Gene Nomenclature. For reference, gene symbols are given below for terms in the preceding list whose abbreviations do not closely resemble the gene symbol:
Term |
Gene Symbol |
|---|---|
A1 |
ADORA1 |
AMPA |
GRIA1 |
δ receptor |
OPRD1 |
D1 |
DRD1 |
H1 |
HRH1 |
5-HT1A |
HTR1A |
κ receptor |
OPRK1 |
μ receptor |
OPRM1 |
M1 |
CHRM1 |
nAChR |
CHRNA1 |
neuromedin K |
TAC3 |
NMDA |
GRIN1 |
σ receptor |
OPRS1 |
substance P |
TAC1 |
transporters (various) |
SLC genes (various, eg, SLC6A1) |
Y1 |
NPY1R |