Parallel-Design Double-blind Trials - AMA Manual of Style

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Parallel-Design Double-blind Trials 

Study Design and Statistics

AMA Manual of Style Committee

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PRINTED FROM AMA MANUAL OF STYLE ONLINE ( © American Medical Association, 2009. All Rights Reserved. Under the terms of the license agreement, an individual user may print out a PDF of a single chapter of a title in AMA Manual of Style Online for personal use (for details see Privacy Policy). date: 30 November 2015

In this study design, participants are assigned to only 1 treatment group of the study. These trials are generally designed to assess whether 1 or more treatments are superior to the others. Participants and those administering the intervention should all be unaware of which intervention individual participants are receiving (“double-blinding”). Ideally, those rating the outcomes should also be blinded to treatment assignment (“triple-blinding”). Blinded parallel-design trials are often the optimal design to compare 2 or more types of drug or other therapy, since known and unknown potentially confounding factors should be randomly distributed between intervention and control groups. The CONSORT

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