Crossover Trials - AMA Manual of Style

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Crossover Trials 

Study Design and Statistics

Margaret A. Winker

and Stephen J. Lurie

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PRINTED FROM AMA MANUAL OF STYLE ONLINE ( © American Medical Association, 2009. All Rights Reserved. Under the terms of the license agreement, an individual user may print out a PDF of a single chapter of a title in AMA Manual of Style Online for personal use (for details see Privacy Policy). date: 25 November 2015

In a crossover trial, participants receive more than 1 of the treatments under investigation, usually in a randomly determined sequence, and with a prespecified amount of time (a ) between sequential treatments. The participants and the investigators are generally to the treatment assignment (double-blinded). This experimental design is often used for evaluating drug treatments. Each participant serves as his or her own control, thereby eliminating variability when comparing treatment effects and reducing the sample size needed to detect a effect. Most considerations of parallel-design randomized trials apply. Rather than indicating which participants were assigned to which condition, the CONSORT flow

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