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Parallel-Design, Double-blind Trials.  

Edward H. Livingston

in AMA Manual of Style: A Guide for Authors and Editors (11 ed.)

Print Publication Year: 
Feb 2020
Published Online: 
Feb 2020
Item type: 
In parallel-design, double-blind trials, participants are assigned to only 1 treatment group of the study. These trials are generally designed to assess whether 1 or more treatments are more effective than the others. Participants and those administering the intervention should all be unaware of which intervention individual participants are receiving (double-blinding). Ideally, those rating the outcomes should also be blinded to treatment assignment (triple-blinding). Blinded parallel-design trials are often the optimal design to compare 2 or more types of drugs or other therapy because known and unknown potentially confounding factors should be randomly distributed between intervention and control groups. Reports of these types of trials should follow the CONSORT reporting guideline (...