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Crossover Trials.  

Edward H. Livingston

in AMA Manual of Style: A Guide for Authors and Editors (11th ed.)

Print Publication Year: 
Feb 2020
Published Online: 
Feb 2020
DOI: 
10.1093/jama/9780190246556.003.0019.022.0009
Item type: 
section
In a crossover trial, participants receive more than 1 of the treatments under investigation, usually in a randomly determined sequence and with a prespecified amount of time (a washout period ) between sequential treatments. The participants and the investigators are generally blinded to the treatment assignment (double-blinded). This experimental design is often used for evaluating drug treatments. Each participant serves as his or her own control, thereby eliminating variability when comparing treatment effects and reducing the sample size needed to detect a statistically ...

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