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Two major criteria are central to the evaluation of manuscripts submitted for publication: importance and quality. Importance involves an assessment of whether the work • Represents a scientific advance (recognizing that individual articles usually convey only small advances) • Has clinical relevance (if the journal is to be read and the information used by practicing clinicians) • Presents new information • Will be of interest to readers An additional component of importance is editorial priority, a composite judgment made by the editor regarding the value of a particular submission relative to other submissions under evaluation at the same time, weighed Less