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The International System for Human Gene Nomenclature (ISGN) was inaugurated in 1979, and has been continually updated. The Human Gene Mapping Nomenclature Committee, which developed the ISGN, put forth a “one human genome one gene language” principle: Certainly there exists a genetic and molecular basis for a single human gene language without dialects. All human nuclear genes as we know them follow the same genetic, molecular, and evolutionary principles…. Thus it is reasonable and logical to develop a standard and consolidated gene nomenclature system rather than have a human gene language based on different gene systems.(p12) The committee, known as Less