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Human Gene Nomenclature.  

Cheryl Iverson

in AMA Manual of Style: A Guide for Authors and Editors (11th edn)

Print Publication Year: 
Feb 2020
Published Online: 
Feb 2020
DOI: 
10.1093/jama/9780190246556.003.0014.022.0041
Item type: 
section
The International System for Human Gene Nomenclature (ISGN), a system for gene symbols, was inaugurated in 19791 , 2 and has been continually updated. The history of naming genes and proteins is littered with redundancy because investigators often make discoveries separately and choose a name without following any sort of naming convention. Hence, the literature, especially literature more than a decade old, can be confusing because the same gene may have multiple names. Standardization helps both research and clinical care. The Human Gene Mapping Nomenclature Committee (HGNC), which developed the ISGN, put forth a “one human genome–one gene language” principle:...

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